HORDB

ID: hor004599
Uniprot ID: Q7YRC3
Protein name: Thymosin beta-4
Gene name: TMSB4
Organism: Notamacropus eugenii (Tammar wallaby) (Macropus eugenii)
Family: Thymosin beta family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Notamacropus (genus), Macropodidae (family), Diprotodontia (order), Metatheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding
GO BP: GO:0007015 actin filament organization
GO CC: GO:0005737 cytoplasm; GO:0005856 cytoskeleton

Sequence: SDKPDMGEIQKFNKSKLKKTETQEKNPLPSKETIEQEKQAGES
Length: 43(2-44)
Propeptide: MSDKPDMGEIQKFNKSKLKKTETQEKNPLPSKETIEQEKQAGES
Signal peptide: NA
Modification: T1 N-acetylserine;T1 Phosphoserine;T3 N6-acetyllysine;T11 N6-acetyllysine;T22 Phosphothreonine;T25 N6-acetyllysine;T30 Phosphoserine;T31 N6-acetyllysine;T33 Phosphothreonine;T38 N6-acetyllysine
Glycosylation: NA
Mutagenesis: NA

Function: Plays an important role in the organization of the cytoskeleton.
Mechanism: Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004599_AF2.pdb

hor004599_ESM.pdb

Mass:	565477	Formula:	C209H348N58O75S
Absent amino acids:	CHRVWY	Common amino acids:	K
pI:	6.81	Basic residues:	9
Polar residues:	11	Hydrophobic residues:	6
Hydrophobicity:	-175.35	Boman Index:	-14311
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	38.6
Instability Index:	5147.21	Extinction Coefficient cystines:	0
Absorbance 280nm:	0